This is, like so many other Manson songs, incredibly complex. Let's hit on the Hollywood AND drug themes for once, hey, kiddies?

A "dope show" was a show in which drug addicts would be put on a stage so people could see the "horrors" drugs cause on people.

I'm sure you all have seen the idiocy on television. Reality television shows depicting people behaving like fuckwads? That's the "dope show"; making money off hollow depictions of decadence, when the real corruption is in the people that sell this.

"Drugs", like with most of the album, is really more of a metaphor for fame (rock 'n' rollers are notorious for their drug usage and addiction) and for things that you get addicted to, making you into a hollow, unfeeling creature... A mechanical animal. ;)